The effects of lifestyle in Alzheimer's disease during the COVID-19 pandemic

Alzheimer's disease (AD) is a multifactorial neurodegenerative disease affected by multiple elements such as exercise, food, and social stimulation. Research has demonstrated the positive effects of exercise such as community-based programs and aerobic activities in reducing rates of decline in cognition. Another protective measure is avoiding red meat and alcohol and instead incorporating a Mediterranean diet to reduce inflammation and inhibit free radicals. Finally, social stimulation can serve to reduce the progression of the disease by increasing a sense of connection and meaningful purpose. COVID-19 has made it difficult for AD patients, especially those living in nursing homes or advanced facilities, to participate in exercise classes due to restrictions, to eat a fresh diet due to resource shortages, and to see friends and family due to social distancing. This chapter delves into the effects of COVID-19 on elements such as physical activity, diet, and social interaction on the disease progression of AD. © 2023 Elsevier Inc. All rights reserved.

Prediction of Complications and Death in Covid-19 Patients with Deranged Liver Function Tests at Time of Admission and Hospitalization

COVID-19 pandemic has affected millions of individuals globally over the last three years and is spreading continuously. In view of different studies and clinical findings, patients suffering with COVID-19 frequently have deranged liver function tests (LFTs), but the clinical significance of this finding is debatable. Objective(s): The present study was aimed to estimate the prevalence, features, and clinical significance of deranged LFTs in COVID-19 infected individuals, who were hospitalized but were not critically ill. Method(s): We conducted a cross sectional from May 2021 to December 2021 at The Akbar Niazi Teaching Hospital Islamabd. A total of 250 COVID-19 patients were included in the current study. The patient's blood samples were collected to get laboratory results, which included LFTs. LFTs were performed at the time of admission and every 5 +/- 2 day throughout the stay. The outcome measure was either death or transfer of the patients to an intensive care unit. Result(s): At the time of admission, 160 patients (64%) showed deranged LFTs. Individuals with deranged LFTs experienced more severe inflammation, swelling, and organ damage than those who didn't. Patients with deranged LFTs had a greater proportion of transfer to the ICU (81 vs 17), hospital stay (17 vs 7 days), and death (17 vs 5) than those with normal LFTs. Conclusion(s): The results of the current investigation demonstrated that LFTs data might forecast the degree of illness in patients with COVID-19 infections at the time of admission and during their hospital stay. Copyright © 2022 Lahore Medical And Dental College. All rights reserved.